Cain is missing his left eye, so he'll only be able to shoot with his right one. This also makes it impossible for him to shoot tears (including special tear effects like Brimstone) while using Technology 2 (though its damage will be significantly buffed). Chemical Peel gives a 50% chance of shooting a blood tear instead of a normal one. However, he still shoots the standard multiple tears with Mutant Spider and The Inner Eye.
Cain's Lucky Foot gives him roughly a 50% chance of winning the Shell Game rather than the normal 33% chance. The chances of the Slot Machine giving items is also increased. This makes it very easy for Cain to "farm" the Arcade room for items and money. Using the Blood Donation Machine to make money to spend on the Shell Game/Slot Machine will frequently be net-positive for Cain, and he can continue spending money and hearts until either the Slot/Blood Donation Machine or the Shell Game vendor explodes/provides Skatole.
The Lucky Foot also turns negative pills into positive pills, but will not affect neutral pills such as Pretty Fly, Telepills, Bombs are Key, I Found Pills, Puberty, Bad Gas, or Friends Till The End. This makes Mom's Bottle Of Pills a much better item.
- Keeping consistent with his eye patch, Cain's tears only shoot from his uncovered eye with a slightly lopsided trajectory path.
- Cain and the familiar Abel are a reference to the Biblical brothers of the same name. His eye patch might hint at Cain's sinful nature and the murder of his brother, after which he was uniquely cursed to walk the Earth forever, but never be harmed. Hence the Lucky Foot and it's effect on pills.
- He is referred to as the "thief" in the Unholy Edition art booklet, with increased speed, less HP, Lucky Foot, and a key (presumably a reference to a lock pick).
"Cain's Eyepatch" - Hold 55 Coins at once in a single playthrough.
"The Bag" - Kill Mom's Heart with Cain.
"The Bomb Bag" - Kill Satan with Cain.
"Abel" - Kill Isaac with Cain.
"Cains Eye" - Kill ??? with Cain. Template:Characters